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Fig. 10 | Journal of Neuroinflammation

Fig. 10

From: Histamine 2/3 receptor agonists alleviate perioperative neurocognitive disorders by inhibiting microglia activation through the PI3K/AKT/FoxO1 pathway in aged rats

Fig. 10

A schematic illustration of the proposed mechanism for H2R/H3R to alleviate microglia-induced neuroinflammation. LPS or stress activates TLR4 and induces microglia to release inflammatory cytokines. PI3K/AKT/FoxO1 axis, as the downstream of TLR4, provides a self-limiting mechanism by which microglia avoid inappropriate long-term overactivation. H2R/H3R can activate PI3K/AKT/FoxO1 signaling, trigger the phosphorylation and nuclear exclusion of FoxO1, and inhibit microglia TLR4 expression and TLR4-mediated inflammatory cytokine release

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Journal of Neuroinflammation

ISSN: 1742-2094