Fig. 5

Downregulation of TrkB reversed LPS-induced microglial activation in BDNF-treated BV2 cells. a The experimental timeline. b–d Levels of TrkB (n = 3), p-p38 (n = 4), and p-JNK (n = 4–5) in the BV2 cells. e, f Levels of TNF (n = 4) and IL-6 (n = 4) in the conditioned media of BV2 cells. Bonferroni post-hoc test: ^$p < 0.05, ^$$p < 0.01, ^$$$p < 0.001: shTrkB versus respective shLacZ group.*p < 0.05, **p < 0.01, ***p < 0.001: LPS(+) versus respective LPS(-) group; ^#p < 0.05, ^##p < 0.01, ^###p < 0.001: BDNF(+) versus respective BDNF(-) group. Data are presented as mean ± S.D