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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Comparison of different optomotor response readouts for visual testing in experimental autoimmune encephalomyelitis-optic neuritis

Fig. 2

Analysis of visual function using OMR, thinning of the inner retinal layers and infiltration of immune cells in the inflammatory EAEON-model over a period of 110 days. Visual acuity tested by spatial frequency (a) and contrast sensitivity (b) at 0.064 c/d (n = 4, note that a higher contrast equals worse visual acuity; compared by GEE analysis). c Clinical EAE score (area under the curve compared by t-test), d change of inner retinal layers (compared using GEE analysis), e representative OCT images (p.i. post-immunization), f infiltrating immune cells in the optic nerve (n = 5), and g representative histological images of optic nerves (H&E staining). The time courses present the results of an EAE experiment with at least four mice per group (*p < 0.05; **p < 0.01; ***p < 0.001)

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