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Fig. 3. | Journal of Neuroinflammation

Fig. 3.

From: Microglia induce the transformation of A1/A2 reactive astrocytes via the CXCR7/PI3K/Akt pathway in chronic post-surgical pain

Fig. 3.

Astrocytes were activated and mainly expressed as the A1 phenotype in the spinal cord after SMIR. a–c Representative blots and quantification of GFAP, C3, and S100A10 in the spinal cord of sham (day 14) and SMIR group rats (n = 7). The expressions of GFAP, C3, and S100A10 were normalized to GAPDH for each sample. GFAP, C3, and S100A10 levels in the sham group were set as 1 for quantification. Compared with the sham rats, *P < 0.05, **P < 0.01, ****P < 0.0001. d–e Double immunofluorescence staining for C3 (red) or S100A10 (red) and GFAP (green) in the spinal cords of sham (day 14) and SMIR group rats (n = 3). Scale bar: 50 μm or 200 μm. d: day; GFAP: glial fibrillary acidic protein; SMIR: skin/muscle incision and retraction

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