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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Three-dimensional morphometric analysis reveals time-dependent structural changes in microglia and astrocytes in the central amygdala and hypothalamic paraventricular nucleus of heart failure rats

Fig. 1

HF-induced morphometric changes in PVN microglia. a Representative confocal images show IBA1-stained microglia in the PVN of HF and sham rats 16 weeks post-surgery. b Brain scheme shows the topographic location of PVN microglia that have been used for the morphometric assessment. The red area within the PVN (heart-shaped nucleus) highlights the fraction of the nucleus where pictures were taken. c Dot-plot graphs show the individual values of PVN microglia for surface area, cell volume, filament length, microglial branches, microglial segments, filament terminals, and IBA 1 intensity for sham rats (N = 1135 cells from 12 rats, pooled) and HF rats at 8, 14, and 16 weeks post-surgery (N = 378 cells from 4 rats, N = 407 cells from 4 rats and N = 399 cells from 4 rats, respectively). *p < 0.05, **p < 0.01, and ***p < 0.0001 vs. respective sham, one-way ANOVA followed by Tukey’s post hoc test

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Journal of Neuroinflammation

ISSN: 1742-2094