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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Three-dimensional morphometric analysis reveals time-dependent structural changes in microglia and astrocytes in the central amygdala and hypothalamic paraventricular nucleus of heart failure rats

Fig. 4

HF-induced somatic swelling of PVN and CeA microglia is correlated with microglial deramification. a Confocal images show a representative example of HF-induced microglial swelling. b, c Bar graphs show the mean microglia somata volume in the PVN and CeA in sham rats (n = 12, pooled) and HF rats at 8, 14, and 16 weeks post-surgery (n = 4/group). dg Plots showing the total number of Sholl intersections as a function of soma volume for individual microglial cells in the PVN of sham (d) and HF (e) rats and in the CeA of sham (f) and HF (g) rats. Red lines represent best-fit lines assuming a non-linear relationship between the total number of Sholl intersections and soma volume. **p < 0.01 and ***p < 0.0001 vs. respective sham, one-way ANOVA followed by Tukey’s post hoc test or Pearson correlation

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