Fig. 5
From: A pivotal role for Interferon-α receptor-1 in neuronal injury induced by HIV-1
HIVgp120 and IFNAR1 cause sex-dependent, differential expression of genes related to neurotransmission systems in the hippocampus. Clustergram heat map of GABA/glutamate system (a) and dopamine/serotonin system (b) showing gene expression profile of WT, HIVgp120tg, IFNAR1-deficient mice with or without HIVgp120. Red indicated the higher gene expression while green indicates the lower gene expression in the sample set. Hippocampus RNA was analyzed using RT2 Profiler PCR Array and the associated Qiagen data analysis software. The heat maps represent significantly changed genes as the averages of three biological replicates. The schematic figure to the right represents pre- and post-synaptic distribution of the differentially expressed genes in neurons of each genotype. Genotypes: WT (WT), HIVgp120tg (GP), IFNAR1KO (KO), and IFNAR1KO × gp120 (KOGP); n = 6 animals (3 males and 3 females) per group/genotype (total n = 24 animals)