Fig. 6
From: A pivotal role for Interferon-α receptor-1 in neuronal injury induced by HIV-1
IFNAR1KO modifies the activity of functional, biological pathways affected by HIVgp120. Gene expression data obtained from RT2 Profiler PCR Arrays were interrogated using Ingenuity Pathway Analysis (IPA) software to analyze neurotransmission-related biological pathways affected by HIVgp120 and IFNAR1 deficiency. Note that most pathways were predicted to be reduced in activity except for long-term potentiation in IFNAR1KO males. The dashed lines at 2 and − 2 on the axis for activation Z-score indicate the significance threshold for a predicted effect on the activity of the given pathway (*P < 0.05); n = 6 animals (3 males (a) and 3 females (b) per group/genotype (total n = 24 animals)