From: A pivotal role for Interferon-α receptor-1 in neuronal injury induced by HIV-1
Upstream regulator | Molecule type | Predicted activation state | Activation z-score | P value | |
---|---|---|---|---|---|
Males | |||||
HIVgp120 | None scored | ||||
IFNAR1KO | None scored | ||||
IFNAR1KOgp120 | CREBBP | Transcription regulator | Inhibited | − 2.236 | 0.0000532 |
Females | |||||
HIVgp120 | HTT | Transcription regulator | Activated | 2.129 | 2.3E−18 |
CREBBP | Transcription regulator | Inhibited | − 2.0 | 0.0000145 | |
IFNAR1KO | CREBBP | Transcription regulator | Inhibited | − 2.0 | 0.000054 |
IFNAR1KOgp120 | CREBBP | Transcription regulator | Inhibited | − 2.0 | 0.0000209 |