Table 4 List of molecules comprising the top-scoring network in male vs female identified by Ingenuity Pathway Analysis (IPA)
From: A pivotal role for Interferon-α receptor-1 in neuronal injury induced by HIV-1
Sex | Molecules in network | Score | Focus molecules | Top diseases and functions |
|---|---|---|---|---|
Males | ADGRA1,ADORA2A,AKT1,AKT3,ARRB2,AVP,CASP3,CREB1,DDC,DLG4,DRD2,FOS,FRAT1,GLS,GRIA1,GRIA3,GRIK2,GRIK5,GRIN2B,GRK6,GSK3B,HTR2A,HTR2C,MAPK1,NPTX2,PIK3CG,PTGS2,SLC17A6,SLC1A2,SLC32A1,SLC6A1,SNCA,SNCAIP,SYN2,TH | 57 | 32 | Behavior, cell-to-cell signaling and interaction, neurological disease |
Females | ADORA1,ADORA2A,AKT1,AKT3,ARRB1,CDK5,CDK5R1,CREB1,DLG4,DRD1,DRD2,EPHB1,GABBR1,GABBR2,GAPDH,GLUL,GNAI1,GRIA1,GRIK2,GRIK5,GRIN1,GRIN2A,GRIN2B,GRIN2C,GRM1,GSK3B,HOMER2,HTR2A,ITPR1,MAPK1,SHANK2,SLC17A6,SLC1A2,SLC6A11,SLC6A3 | 66 | 35 | Behavior, cell-to-cell signaling and interaction, nervous system development and function |