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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: The glycosyltransferase EXTL2 promotes proteoglycan deposition and injurious neuroinflammation following demyelination

Fig. 8

Schematic showing the phenotypes observed in EXTL2−/− mice with lysolecithin-induced lesions. EXTL2−/− animals have greater versican deposition into the lesion following demyelination, and this is correlated to a larger area of damage and exacerbated axon dropout within the lesion. In addition, greater amounts of Iba1 immunoreactivity was seen in EXTL2−/− lesions, indicative of a more inflammatory milieu compared to that of wild-type animals

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