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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Thrombomodulin facilitates peripheral nerve regeneration through regulating M1/M2 switching

Fig. 4

TM improves nerve regeneration after transverse nerve injury. a Gross view of regenerating sciatic nerves showing that TM-treated nerves have a wider diameter than those treated with PBS. b Light microscopic (upper row) and transmission electron micrographs (lower row) of sciatic nerve sections demonstrating an apparent increase in axon number, axon area, and myelin thickness in TM-treated nerve sections in comparison with those treated with PBS. Muscle mass and muscular structure were better preserved in the TM group. n = 3. c Quantification of axon number per unit, d axon area, and myelin sheath thickness. e Gross view of the gastrocnemius muscles. f Hematoxylin and eosin staining of gastrocnemius muscle sections showing an increase in RMW and muscle fiber in TM-treated nerves. n = 3. g Quantification of RMW and muscle fiber area. Scale bar, 100 μm (light microscopy). Scale bar, 2 μm (electron micrograph). Mean ± SD. *p < 0.05 compared with the PBS group

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