Fig. 3
Pan-injury astrocyte gene expression signature. Heatmaps depict log2(fold change) of upregulated (a–c) and downregulated (d) genes in both acute injury (AI) and chronic neurodegeneration (ND). The pan-injury (PAN) signature consists of upregulation of cytoskeleton (i.e., Gfap, Vim) (a), extracellular matrix (i.e., Cd44, Timp1) (b), and immune response (i.e., C3, interferon signaling, STAT pathway) (c), and downregulation of lipid metabolism (i.e., Hmgcs1, Sqle) among other genes (d)