Skip to main content
Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: NF-κB p65-dependent transcriptional regulation of histone deacetylase 2 contributes to the chronic constriction injury-induced neuropathic pain via the microRNA-183/TXNIP/NLRP3 axis

Fig. 1

NF-κB p65 and HDAC2 are highly expressed in the dorsal horn of the CCI rat spinal cord. a PWT and PWL measured in the dorsal horn of CCI rats (n = 10), normal rats (n = 10), and sham-operated rats (n = 10). b, c Protein levels of NF-κB p65 and HDAC2 in dorsal horn of CCI rat spinal cord at different time points following CCI modeling determined by Western blot analysis, normalized to GAPDH. d Expression of NF-κB p65, NF-κB p-p65, and HDAC2 with Iba-1-labeled microglial cells of CCI rat spinal cord detected by immunofluorescence staining. Iba-1 is a marker molecule of microglial cells. Image J software was used to analyze the IOD (scale bar = 25 μm). *relative to sham-operated or normal rats indicates p < 0.05. All measurement data were expressed as the mean ± standard deviation. Unpaired t test was used to analyze data between the two groups, one-way ANOVA and Tukey’s post hoc test to analyze data among multiple groups, and repeated-measures ANOVA with Bonferroni post hoc test to analyze data at different time points

Back to article page