Skip to main content

Table 1 Biomarkers of inflammation in OSAS patients

From: The relationship between inflammation and neurocognitive dysfunction in obstructive sleep apnea syndrome

Reference Number of subjects Detecting parameter Cytokines levels alteration Cytokines concentrations correlated with
Nadeem et al. 2013 [33] Meta-analysis of 2952 OSAS and 2784 controls CRP, TNF-α, IL-6, IL-8, ICAM, VCAM, and selectins CRP↑, TNF-α↑, IL-6↑, IL-8↑, ICAM↑, VCAM↑, and selectins↑ Age, BMI, AHI
Bouloukaki et al. 2017 [34] 858 OSAS; 190 controls CRP, fibrinogen, UA and ESR CRP↑, fibrinogen↑, UA↑ Gender, BMI, AHI, ODI and mean and minimum SaO2, TST90 and active somking
Bozic et al. 2018 [35] 50 OSAS; 25 controls TNF-α, IL-6 and hsCRP TNF-α↑, IL-6↑, hsCRP↑ Plasma adropin levels
Motamedi et al. 2018 [36] 50 OSAS; 24 controls Tau, IL-6, IL-10, CRP, TNF-α and Aβ Tau↑, IL-6↑ AHI
Svatikova et al. 2003 [37] 20 OSAS; 17 controls SAA SAA↑ AHI
Sozer et al. 2018 [38] 60 OSAS; 24 controls CRP, PTX-3, ProCT, IL-33 and sST2 PTX-3↑, IL-33↑, and sST2↑ BMI, ODI, minimum SaO2
  1. CRP C-reactive protein, TNF-α tumor necrosis factor-α, IL interleukin, ICAM intercellular adhesion molecules, VCAM vascular cell adhesion molecule, BMI body mass index, AHI apnea hypopnea index, UA uric acid, ESR erythrocyte sedimentation rate, ODI oxygen desaturation index, TST90 sleep time spent with SaO2 less than 90%, amyloid beta, SAA serum amyloid A, PTX-3 pentraxin-3, ProCT procalcitonin, sST2 soluble receptor ST2