Fig. 9
From: Microglial burden, activation and dystrophy patterns in frontotemporal lobar degeneration
Examples of dystrophic microglia in controls and genetic FTLD subtypes. Differing severities of dystrophic Iba1-positive microglia are visible in frontal grey (FG) matter (a, c, e, g) and frontal subcortical white (FW) matter (b, d, f, h) of controls (a, b) and FTLD-GRN (c, d), FTLD-C9orf72 (e, f) and FTLD-MAPT (g, h) cases. Scale bar represents 50 μm in all images. Note that in the FTLD-GRN case there is particularly extensive dystrophy, which is worse in white matter, where there is generalised punctate Iba1 staining consistent with severe cellular disruption (d). Images were taken from the following cases (in Supplementary Table 1): control (case 4), FTLD-GRN (case 40, has FTLD-TDPA), FTLD-C9orf72 (case 42, has FTLD-TDPA) and FTLD-MAPT (case 16)