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Table 1 Demographics of cases and controls

From: Microglial burden, activation and dystrophy patterns in frontotemporal lobar degeneration

Pathological diagnosis

N

Genetic mutation (N)

Clinical diagnosis (N)

Sex

(M/F)

Mean (range) age at symptom onset in years

Mean (range) age at death in years

Mean (range) disease duration in years

Mean (range)

post-mortem delay (hours)

Controls

5

n/a

Control

1/4

n/a

67.4

(38–80)

n/a

45.7

(24.0–80.6)

AD

5

n/a

Amnestic AD

3/2

58.8

(49–65)

69.2

(62.0–73.0)

10.4

(5.0–17.0)

45.8

(31.1–76.7)

FTLD

50

Sporadic = 31

Genetic = 19:

GRN = 5

C9orf72 = 8

MAPT = 5

TBK1 = 1

bvFTD = 23

nfvPPA = 8

FTD-MND = 8

svPPA = 5

PSPS = 5

CBS = 1

29/21

57.8

(37–66)

66.5

(51.3–84.0)

8.7

(2.1–18.7)

60.7

(10.8–157.6)

FTLD subgroups

 FTLD-tau

20

Sporadic = 15

Genetic = 5

(MAPT)

bvFTD = 10

nfvPPA = 4

PSPS = 5

CBS = 1

13/7

58.2

(37–71)

68.1

(52.4–84.0)

9.9

(5.5–16.4)

54.9

(24.0–103.3)

 FTLD-CBD

5

All sporadic

nfvPPA = 3

PSPS =1

CBS = 1

2/3

60.2

(57–65)

69.0

(64.8–73.8)

8.8

(5.5–11.1)

68.9

(37.2–103.3)

 FTLD-MAPT

5

Genetic = 5

(all MAPT 10 + 16)

bvFTD = 5

2/3

48.0

(37–58)

59.6

(52.4–68.4)

11.6

(8.1–16.4)

45.9

(24.0–64.0)

 FTLD-Picks

5

All sporadic

bvFTD = 5

5/0

57.6

(52–64)

68.1

(63.5–75.6)

10.5

(5.5–15.6)

47.8

(24.0–94.7)

 FTLD-PSP

5

All sporadic

PSPS = 4

nfvPPA = 1

4/1

67.0

(62–71)

75.6

(68.0–84.0)

8.6

(6.0–13.0)

57.2

(25.5–86.4)

 FTLD-TDP

26

Sporadic = 12

Genetic = 14

C9orf72 = 8

GRN = 5

TBK1 = 1

bvFTD = 9

nfvPPA = 4

FTD-MND = 8

svPPA = 5

12/14

59.4

(50–76)

67.2

(53.1–78.6)

7.8

(2.1–18.7)

68.8 *

(10.8–157.6)

 FTLD-TDPA

16

Sporadic = 5

Genetic = 11

C9orf72 = 5

GRN = 5

TBK1 = 1

bvFTD = 7

nfvPPA = 4

FTD-MND = 5

7/9

60.6

(50–76)

67.0

(53.1–78.6)

6.4

(2.1–10.3)

77.3

(29.3–157.6)

 FTLD-TDPB

5

Sporadic = 2

Genetic = 3 (C9orf72)

bvFTD = 2

FTD-MND = 3

2/3

56.2

(50–63)

62.1

(56.2–67.2)

5.9

(4.2–8.1)

68.5

(10.8–96.0)

 FTLD-TDPC

5

All sporadic

svPPA = 5

3/2

58.8

(52–64)

73.0

(65.4–78.6)

14.2

(10.3–18.7)

43.8

(19.0–83.7)

 FTLD-FUS (all aFTLD-U)

4

All sporadic

bvFTD = 4

4/0

45.4

(40–51)

53.9

51.3–60.4

8.4

(5.5–11.3)

39.0

(12.0–72.0)

 FTLD cases used for genetic group analysis (all included in groups above)

15

GRN = 5

(all FTLD-TDPA)

MAPT = 5

(all FTLD-MAPT)

C9orf72 = 5

(all FTLD-TDPA)

bvFTD = 4

nfvPPA = 1

bvFTD = 5

FTD-MND = 3

nfvPPA = 2

2/3

2/3

1/4

58.0

(62–67)

48.0

(37–58)

60.8

(55–68)

64.6

(55.3–74.2)

59.6

(52.4–68.4)

68.6

(62.7–75.1)

6.6

(5.3–8.4)

11.6

(8.1–16.4)

7.8

(5.7–10.3)

83.1

(29.3–157.6)

45.9

(24.0–64.0)

78.7

(51.9–107.1)

  1. Summary of demographics of FTLD and AD cases and controls analysed. N number of cases, M male, F female