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Table 3 Diffusivities in regions of interest (ROIs) that showed HIV or MJ effects

From: Microstructural brain abnormalities in HIV+ individuals with or without chronic marijuana use

Brain region Subject group 2-way ANCOVA
Co-variate Main effect HIV × MJ
SN SN + MJ HIV HIV + MJ Age ALC TS HIV MJ
Axial diffusivity
 BCC_R 1.524 ± 0.01 1.505 ± 0.012 1.561 ± 0.011 1.542 ± 0.011 0.001 0.418 0.608 0.004 0.148 ns
 SCC_L 1.502 ± 0.011 1.5 ± 0.012 1.55 ± 0.012 1.548 ± 0.012 < 0.001 0.457 0.932 < 0.001* 0.899 ns
 SLF_L 1.072 ± 0.006 1.075 ± 0.007 1.095 ± 0.007 1.099 ± 0.007 0.001 0.734 0.305 0.003 0.690 ns
 UNC_R 1.107 ± 0.008 1.082 ± 0.009 1.119 ± 0.009 1.094 ± 0.009 0.129 0.951 0.434 0.241 0.024 ns
 CGC_R 1.175 ± 0.01 1.17 ± 0.012 1.185 ± 0.011 1.18 ± 0.011 0.001 0.406 0.034 0.442 0.694 ns
 EC_L 1.106 ± 0.008 1.098 ± 0.009 1.123 ± 0.009 1.115 ± 0.009 < 0.001 0.790 0.003 0.066 0.422 ns
 SCR_L 1.038 ± 0.011 1.043 ± 0.012 1.068 ± 0.012 1.073 ± 0.012 < 0.001 0.697 0.056 0.020 0.727 ns
 SFO_R 1.115 ± 0.018 1.1 ± 0.02 1.159 ± 0.019 1.145 ± 0.02 0.001 0.635 0.243 0.040 0.538 ns
Radial diffusivity
 ALIC_L 0.53 ± 0.006 0.531 ± 0.007 0.551 ± 0.007 0.552 ± 0.007 < 0.001 0.829 0.279 0.004 0.889 ns
 ALIC_R 0.55 ± 0.006 0.544 ± 0.007 0.57 ± 0.007 0.563 ± 0.007 < 0.001 0.499 0.441 0.012 0.461 ns
 PCR_L 0.575 ± 0.006 0.574 ± 0.006 0.597 ± 0.006 0.596 ± 0.006 < 0.001 0.841 0.026 0.002 0.943 ns
 PCR_R 0.608 ± 0.008 0.601 ± 0.009 0.634 ± 0.009 0.627 ± 0.009 < 0.001 0.271 0.070 0.010 0.488 ns
 SCR_L 0.539 ± 0.006 0.539 ± 0.007 0.561 ± 0.007 0.562 ± 0.007 0.003 0.685 0.057 0.003 0.971 ns
 SCR_R 0.533 ± 0.007 0.533 ± 0.008 0.55 ± 0.007 0.551 ± 0.007 0.002 0.917 0.057 0.030 0.966 ns
 SFO_L 0.554 ± 0.01 0.562 ± 0.012 0.581 ± 0.011 0.59 ± 0.011 0.001 0.935 0.235 0.028 0.509 ns
 SFO_R 0.556 ± 0.011 0.553 ± 0.013 0.59 ± 0.012 0.587 ± 0.012 < 0.001 0.492 0.336 0.013 0.807 ns
 PLIC_L 0.453 ± 0.005 0.458 ± 0.005 0.463 ± 0.005 0.467 ± 0.005 0.010 0.755 0.446 0.093 0.464 ns
 RLIC_L 0.57 ± 0.004 0.57 ± 0.005 0.582 ± 0.005 0.582 ± 0.005 0.005 0.761 0.513 0.022 0.989 ns
 EC_L 0.602 ± 0.005 0.593 ± 0.006 0.618 ± 0.006 0.609 ± 0.006 < 0.001 0.396 0.013 0.019 0.213 ns
 IFO_L 0.593 ± 0.006 0.587 ± 0.006 0.606 ± 0.006 0.6 ± 0.006 0.001 0.600 0.107 0.057 0.367 ns
 SLF_L 0.566 ± 0.005 0.562 ± 0.006 0.581 ± 0.005 0.578 ± 0.006 0.016 0.366 0.064 0.011 0.578 ns
 SLF_R 0.579 ± 0.007 0.571 ± 0.008 0.598 ± 0.007 0.591 ± 0.007 0.008 0.366 0.044 0.020 0.412 ns
Mean diffusivity
 Thal_L 0.739 ± 0.004 0.738 ± 0.005 0.749 ± 0.005 0.748 ± 0.005 0.002 0.166 0.414 0.063 0.934 ns
 Caudate_R 0.806 ± 0.008 0.802 ± 0.009 0.829 ± 0.009 0.824 ± 0.009 0.019 0.788 0.102 0.024 0.693 ns
 GP_L 0.735 ± 0.01 0.748 ± 0.012 0.76 ± 0.011 0.773 ± 0.011 0.647 0.027 0.945 0.050 0.328 ns
 GP_R 0.782 ± 0.01 0.769 ± 0.011 0.778 ± 0.01 0.811 ± 0.011 0.129 0.458 0.213 0.772 0.412 0.029
  1. All uncorrected p values < 0.05 from two-way ANCOVA are shown. p values < 0.05 for HIV or MH main effects of their interaction are shown in bold
  2. ALIC anterior limb of the internal capsule, BCC body of the corpus callosum, CGC cingulum, cingulate gyrus part, EC external capsule, GP globus pallidus, IFO inferior fronto-occipital fasciculus, PCR posterior corona radiata, PLIC posterior limb of the internal capsule, RLIC retrolenticular part of the internal capsule, SCC splenium of the corpus callosum, SCR superior corona radiata, SLF superior longitudinal fasciculus, SFO superior fronto-occipital fasciculus, Thal thalamus, UNC uncinate fasciculus, ns not significant (p ≥ 0.05)
  3. *p values remained significant after Holm correction for multiple comparisons