Microstructural brain abnormalities in HIV+ individuals with or without chronic marijuana use

Wang, Hannah A.; Liang, Hua-Jun; Ernst, Thomas M.; Oishi, Kenichi; Chang, Linda

doi:10.1186/s12974-020-01910-5

Journal of Neuroinflammation

Table 3 Diffusivities in regions of interest (ROIs) that showed HIV or MJ effects

From: Microstructural brain abnormalities in HIV+ individuals with or without chronic marijuana use

Brain region	Subject group				2-way ANCOVA
	Subject group				Co-variate			Main effect		HIV × MJ
	SN	SN + MJ	HIV	HIV + MJ	Age	ALC	TS	HIV	MJ	HIV × MJ
Axial diffusivity
BCC_R	1.524 ± 0.01	1.505 ± 0.012	1.561 ± 0.011	1.542 ± 0.011	0.001	0.418	0.608	0.004	0.148	ns
SCC_L	1.502 ± 0.011	1.5 ± 0.012	1.55 ± 0.012	1.548 ± 0.012	< 0.001	0.457	0.932	< 0.001*	0.899	ns
SLF_L	1.072 ± 0.006	1.075 ± 0.007	1.095 ± 0.007	1.099 ± 0.007	0.001	0.734	0.305	0.003	0.690	ns
UNC_R	1.107 ± 0.008	1.082 ± 0.009	1.119 ± 0.009	1.094 ± 0.009	0.129	0.951	0.434	0.241	0.024	ns
CGC_R	1.175 ± 0.01	1.17 ± 0.012	1.185 ± 0.011	1.18 ± 0.011	0.001	0.406	0.034	0.442	0.694	ns
EC_L	1.106 ± 0.008	1.098 ± 0.009	1.123 ± 0.009	1.115 ± 0.009	< 0.001	0.790	0.003	0.066	0.422	ns
SCR_L	1.038 ± 0.011	1.043 ± 0.012	1.068 ± 0.012	1.073 ± 0.012	< 0.001	0.697	0.056	0.020	0.727	ns
SFO_R	1.115 ± 0.018	1.1 ± 0.02	1.159 ± 0.019	1.145 ± 0.02	0.001	0.635	0.243	0.040	0.538	ns
Radial diffusivity
ALIC_L	0.53 ± 0.006	0.531 ± 0.007	0.551 ± 0.007	0.552 ± 0.007	< 0.001	0.829	0.279	0.004	0.889	ns
ALIC_R	0.55 ± 0.006	0.544 ± 0.007	0.57 ± 0.007	0.563 ± 0.007	< 0.001	0.499	0.441	0.012	0.461	ns
PCR_L	0.575 ± 0.006	0.574 ± 0.006	0.597 ± 0.006	0.596 ± 0.006	< 0.001	0.841	0.026	0.002	0.943	ns
PCR_R	0.608 ± 0.008	0.601 ± 0.009	0.634 ± 0.009	0.627 ± 0.009	< 0.001	0.271	0.070	0.010	0.488	ns
SCR_L	0.539 ± 0.006	0.539 ± 0.007	0.561 ± 0.007	0.562 ± 0.007	0.003	0.685	0.057	0.003	0.971	ns
SCR_R	0.533 ± 0.007	0.533 ± 0.008	0.55 ± 0.007	0.551 ± 0.007	0.002	0.917	0.057	0.030	0.966	ns
SFO_L	0.554 ± 0.01	0.562 ± 0.012	0.581 ± 0.011	0.59 ± 0.011	0.001	0.935	0.235	0.028	0.509	ns
SFO_R	0.556 ± 0.011	0.553 ± 0.013	0.59 ± 0.012	0.587 ± 0.012	< 0.001	0.492	0.336	0.013	0.807	ns
PLIC_L	0.453 ± 0.005	0.458 ± 0.005	0.463 ± 0.005	0.467 ± 0.005	0.010	0.755	0.446	0.093	0.464	ns
RLIC_L	0.57 ± 0.004	0.57 ± 0.005	0.582 ± 0.005	0.582 ± 0.005	0.005	0.761	0.513	0.022	0.989	ns
EC_L	0.602 ± 0.005	0.593 ± 0.006	0.618 ± 0.006	0.609 ± 0.006	< 0.001	0.396	0.013	0.019	0.213	ns
IFO_L	0.593 ± 0.006	0.587 ± 0.006	0.606 ± 0.006	0.6 ± 0.006	0.001	0.600	0.107	0.057	0.367	ns
SLF_L	0.566 ± 0.005	0.562 ± 0.006	0.581 ± 0.005	0.578 ± 0.006	0.016	0.366	0.064	0.011	0.578	ns
SLF_R	0.579 ± 0.007	0.571 ± 0.008	0.598 ± 0.007	0.591 ± 0.007	0.008	0.366	0.044	0.020	0.412	ns
Mean diffusivity
Thal_L	0.739 ± 0.004	0.738 ± 0.005	0.749 ± 0.005	0.748 ± 0.005	0.002	0.166	0.414	0.063	0.934	ns
Caudate_R	0.806 ± 0.008	0.802 ± 0.009	0.829 ± 0.009	0.824 ± 0.009	0.019	0.788	0.102	0.024	0.693	ns
GP_L	0.735 ± 0.01	0.748 ± 0.012	0.76 ± 0.011	0.773 ± 0.011	0.647	0.027	0.945	0.050	0.328	ns
GP_R	0.782 ± 0.01	0.769 ± 0.011	0.778 ± 0.01	0.811 ± 0.011	0.129	0.458	0.213	0.772	0.412	0.029

All uncorrected p values < 0.05 from two-way ANCOVA are shown. p values < 0.05 for HIV or MH main effects of their interaction are shown in bold
ALIC anterior limb of the internal capsule, BCC body of the corpus callosum, CGC cingulum, cingulate gyrus part, EC external capsule, GP globus pallidus, IFO inferior fronto-occipital fasciculus, PCR posterior corona radiata, PLIC posterior limb of the internal capsule, RLIC retrolenticular part of the internal capsule, SCC splenium of the corpus callosum, SCR superior corona radiata, SLF superior longitudinal fasciculus, SFO superior fronto-occipital fasciculus, Thal thalamus, UNC uncinate fasciculus, ns not significant (p ≥ 0.05)
*p values remained significant after Holm correction for multiple comparisons

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ISSN: 1742-2094

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