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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: T cell infiltration and upregulation of MHCII in microglia leads to accelerated neuronal loss in an α-synuclein rat model of Parkinson’s disease

Fig. 1

Bar graph showing results from the cylinder test for paw bias at three different time points: baseline (before surgery), 1-month post-surgery, and 2-month post-surgery. Heterozygous nude rats injected with AAV9-αsyn slowly developed a paw bias with more right paw touches that became significant at 2 months post-surgery when compared to GFP-injected controls (Two-way ANOVA, mixed-effects analysis p < 0.0001; F (1.96, 79.15) = 13.31 post hoc analysis: Tukey’s multiple comparison test, p = 0.0003), whereas T cell deficient nude rats injected with AAV9-αsyn did not develop a significant paw bias at any time point tested. Ten animals per group were used (nude rats—GFP, α-synuclein; heterozygous nude rats—GFP, α-synuclein). The bars in the graph represent mean±standard error of the mean

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Journal of Neuroinflammation

ISSN: 1742-2094