Skip to main content
Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: T cell infiltration and upregulation of MHCII in microglia leads to accelerated neuronal loss in an α-synuclein rat model of Parkinson’s disease

Fig. 5

a, c Representative photomicrographs of CD4 T cell staining. b, d Representative photomicrographs of CD8 T cell staining. a, b T cell deficient (nude) rats injected with AAV9-human α-synuclein (αsyn) (n = 5); c, d T cell competent (heterozygous nude) rats injected with AAV9-human α-synuclein (n = 5). e Bar graph shows the number of CD4 T cells in the injected side of the SNpc region. A significant difference in the number of CD4 T cells was observed between nude and heterozygous nude rats injected with AAV9-α-syn. f Bar graph shows the number of CD8 T cells in the injected side of the SNpc region. A significant difference was observed in the number of CD8 T cells between nude and heterozygous nude rats injected with AAV9-αsyn (One way ANNOVA p < 0.0001; F (3, 14) = 426.6; post hoc analysis: Tukey’s multiple comparison test, p < 0.0001). The bars in the graph represent mean ± standard error of the mean

Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094