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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Memantine ameliorates motor impairments and pathologies in a mouse model of neuromyelitis optica spectrum disorders

Fig. 1

Oral administration of memantine ameliorates human AQP4-IgG-induced motor impairments in mice. a Animal groups and experimental procedures. b, c Time required (b) and number of paw slips (c) during walking across a 1.2 × 80 cm (width × length) beam in beam walking test on IgG(AQP4+) mice treated with preventive memantine or vehicle at 1, 4, and 8 days post-injection (dpi) or with therapeutic memantine or vehicle at 8 dpi. IgG(con) mice treated with vehicle were used as a sham control. d, e Time required (d) and number of paw slips (e) during walking across a 0.6 × 80 cm (width × length) beam in beam walking test on mice in different groups. n = 8 per group. Data are mean ± SEM. One-way ANOVA with Tukey-Kramer post hoc test. ns, not significant; *p < 0.05; **p < 0.01; ***p < 0.001

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