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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Therapeutic Trem2 activation ameliorates amyloid-beta deposition and improves cognition in the 5XFAD model of amyloid deposition

Fig. 2

Intracranial injection of AL002a activates microglia and ameliorates amyloid deposition in 5XFAD mice. Panel a shows the anti-mouse IgG immunohistochemistry in the frontal cortex and hippocampus of mice receiving intracranial injection of either control IgG or AL002a. Arrows indicate the exact injection site. Panel b shows the RT-PCR data obtained from the right hippocampus of the injected mice. All data are shown as a fold-change relative to the mean of the control antibody-injected mice. Data were analyzed using single, one-way ANOVA measures for each gene of interest, using a Bonferroni correction for multiple comparisons. Panel c shows the microglial activation (CD11b) in the hippocampus (images shown) and frontal cortex following intracranial injection of control antibody or AL002a. Panel d shows the total Aβ deposition in the hippocampus (images shown) and frontal cortex following intracranial injection of control antibody or AL002a. Panel e shows Congo red labeling of compact amyloid deposits in the hippocampus (images shown) and frontal cortex following intracranial injection of control antibody or AL002a. For all graphs, black bars represent AL002a while gray bars represent control antibody. *P < 0.05, **P < 0.01. For images in ae, magnification = ×40, scale bars shown = 120 μm

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