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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Ingestion of Lactobacillus intestinalis and Lactobacillus reuteri causes depression- and anhedonia-like phenotypes in antibiotic-treated mice via the vagus nerve

Fig. 6

Effects of SDV on behavioral abnormalities after transplantation of L. intestinalis and L. reuteri in the antibiotic-treated mice. a Body weight (repeated measure two-way ANOVA, SDV: F1,28 = 8.910, P = 0.006; microbiota transplantation: F1,28 = 0.317, P = 0.578; interaction: F1,28 = 1.713, P = 0.201). b Locomotion (two-way ANOVA, SDV: F1,28 = 1.716, P = 0.201; microbiota transplantation: F1,28 = 0.015, P = 0.905; interaction: F1,28 = 1.649, P = 0.210). c TST (two-way ANOVA, SDV: F1,28 = 9.916, P = 0.004; microbiota transplantation: F1,28 = 25.222, P < 0.001; interaction: F1,28 = 10.069, P = 0.004). d FST (two-way ANOVA, SDV: F1,28 = 10.181, P = 0.003; microbiota transplantation: F1,28 = 4.893, P = 0.035; interaction: F1,28 = 6.957, P = 0.013). e SPT (two-way ANOVA, SDV: F1,28 = 4.820, P = 0.037; microbiota transplantation: F1,28 = 19.414, P < 0.001; interaction: F1,28 = 5.943, P = 0.021). f Plasma IL-6 (two-way ANOVA, SDV: F1,28 = 64.671, P < 0.001; microbiota transplantation: F1,28 = 92.048, P < 0.001; interaction: F1,28 = 57.921, P < 0.001). g GluA1 (two-way ANOVA, SDV: F1,28 = 43.231, P < 0.001; microbiota transplantation: F1,28 = 24.521, P < 0.001; interaction: F1,28 = 2.093, P = 0.159). h PSD-95 (two-way ANOVA, SDV: F1,28 = 4.376, P = 0.046; microbiota transplantation: F1,28 = 4.560, P = 0.042; interaction: F1,28 = 1.945, P = 0.174). Data are shown as mean ± S.E.M. (n = 8). *P < 0.05, **P < 0.01, ***P < 0.001. NS not significant, sham + W sham + water-treated mice, SDV + W SDV + water-treated mice, SDV + M SDV + microbiota transplantation, sham + M sham + microbiota transplantation

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