Fig. 5

Panx1 deletion in myeloid cells reduces blood–brain barrier leakage after TBI. a Immunoglobulin (IgG) heavy chain and light chain, markers for blood–brain barrier damage, are reduced in Cx3cr1-Cre::Panx1^fl/fl mice (n = 5) compared with Panx1^fl/fl mice (n = 5). Light chain: *P < 0.05, ***P < 0.001, One-way ANOVA (F_{3, 14} = 12.04) and Tukey’s post hoc test. Heavy chain: **P < 0.01, ***P < 0.001, One-way ANOVA (F_3,14 = 16.89) and Tukey’s post hoc test. Values are expressed as mean ± SD optical density relative to GAPDH. Each dot represents an individual animal. b Magnevist present into the parenchyma was calculated by subtracting basal Magnevist in the parenchyma from post-dose. Unpaired Student’s two-tailed t test (t = 4.361, df = 8, P = 0.0024). Values are expressed as the mean difference in (±SD) Magnevist signal before and after dose. Each dot represents an individual animal. *P < 0.05.