From: Prognostic significance of plasma IL-2 and sIL-2Rα in patients with first-ever ischaemic stroke
Baseline characteristics | All (201) | Favourable outcome (130) | Unfavourable outcome (71) | p value |
---|---|---|---|---|
Age, year | 64.11 ± 13.29 | 61.86 ± 12.33 | 68.23 ± 14.07 | 0.001 |
Male, n (%) | 149 (74.13) | 99 (76.15) | 50 (70.42) | 0.375 |
Time from onset, h | 3.00 (1.50–5.10) | 2.90 (1.30–4.55) | 3.20 (1.80–6.80) | 0.086 |
Baseline systolic BP, mmHg | 150 (140–168.5) | 152 (140–170) | 148 (138–168) | 0.206 |
Baseline diastolic BP, mmHg | 87.0 (78.0–93.0) | 85.0 (77.8–93.3) | 90.0 (79.0–92.0) | 0.875 |
Baseline NIHSS score | 5.0 (3.0–11.0) | 4.0 (2.0–6.0) | 13.0 (9–17.0) | 0.000 |
Recanalization treatment | 103 (51.24) | 74 (56.92) | 29 (40.85) | 0.029 |
Risk factors, n (%) | ||||
Hypertension | 132 (65.67) | 82 (63.08) | 50 (70.42) | 0.294 |
Diabetes mellitus | 82 (40.80) | 47 (36.15) | 35 (49.30) | 0.070 |
Coronary heart disease | 46 (22.89) | 24 (18.46) | 22 (30.90) | 0.043 |
Atrial fibrillation | 32 (15.92) | 11 (8.46) | 21 (29.58) | 0.000 |
Stroke aetiology, n (%) | ||||
Thrombotic | 147 (73.13) | 94 (72.31) | 53 (74.65) | 0.721 |
Embolic | 15 (7.46) | 10 (7.69) | 5 (7.04) | 0.867 |
Lacunar | 39 (19.40) | 26 (20.00) | 13 (18.31) | 0.772 |
Clinical parameters, median (IQR) | ||||
Neutrophil-to-lymphocyte ratio | 2.90 (2.03–5.25) | 2.55 (1.80–4.07) | 4.53 (2.35–9.08) | 0.000 |
Baseline glucose, mmol/L | 6.77 (5.71–8.94) | 6.33 (5.56–8.04) | 8.30 (6.47–10.54) | 0.000 |
Triglycerides, mmol/L | 1.45 (0.96–2.47) | 1.70 (1.0–-2.69) | 1.20 (0.76–1.72) | 0.002 |
Total cholesterol, mmol/L | 4.53 (3.79–5.43) | 4.69 (3.93–5.59) | 4.26 (3.60–5.10) | 0.008 |
High-density lipoprotein, mmol/L | 1.18 (1.00–1.39) | 1.17 (0.97–1.39) | 1.23 (1.05–1.37) | 0.373 |
Low-density lipoprotein, mmol/L | 2.70 (2.03–3.42) | 2.79 (2.05–3.62) | 2.45 (1.99–3.11) | 0.069 |
Biomarkers (pg/ml), median (IQR) | ||||
sIL-2Rα | 947.63 (689.61–1370.90) | 812.92 (631.42–1160.78) | 1331.25 (947.63–1657.90) | 0.000 |
IL-2 | 28.08 (17.28–40.85) | 29.53 (18.67–46.19) | 24.29 (15.73–36.60) | 0.027 |