Table 2 The effect of MIA induced by LPS and Poly I:C treatment on the gene expression of M1-like microglial markers and pro-inflammatory factors: MhcII, Cd68, Cd40, iNos, Il-1β, Tnf-α and Il-6, and M2-like microglial markers and anti-inflammatory factors: Arg1, Igf-1, Tgf-β, Il-4 and Il-10, in the hippocampi (Hp) and the frontal cortices (Cx) of offspring at PND7. The mRNA levels were measured using qRT-PCR with n = 4–8 in each group. The results are presented as the average fold change ± SEMs

 MhcII

1.03 ± 0.09

0.83 ± 0.06

0.98 ± 0.18

0.91 ± 0.11

1.02 ± 0.08

0.84 ± 0.12

1.17 ± 0.24

0.90 ± 0.11

 Cd68

1.09 ± 0.07

1.44 ± 0.29

1.05 ± 0.13

1.02 ± 0.13

1.08 ± 0.18

0.76 ± 0.09

0.93 ± 0.03

0.81 ± 0.07

 Cd40

1.01 ± 0.04

1.16 ± 0.14

0.97 ± 0.07

1.36 ± 0.14*

1.02 ± 0.09

0.92 ± 0.10

1.00 ± 0.04

0.80 ± 0.05*

 iNos

0.96 ± 0.34

1.44 ± 0.21

0.92 ± 0.20

1.03 ± 0.21

0.81 ± 0.11

1.49 ± 0.26*

1.14 ± 0.21

1.21 ± 0.29

 Il-1β

1.02 ± 0.08

1.79 ± 0.27*

1.02 ± 0.09

1.16 ± 0.12

1.04 ± 0.11

1.09 ± 0.07

1.03 ± 0.10

0.81 ± 0.05

 Tnf-α

1.00 ± 0.03

1.63 ± 0.29*

1.02 ± 0.08

1.22 ± 0.14

1.08 ± 0.17

0.82 ± 0.06

1.04 ± 0.12

0.83 ± 0.07

 Il-6

1.02 ± 0.08

1.24 ± 0.11

1.03 ± 0.10

1.20 ± 0.13

1.05 ± 0.11

0.92 ± 0.08

0.94 ± 0.12

1.37 ± 0.11*

 Arg1

1.01 ± 0.05

1.59 ± 0.25*

1.02 ± 0.08

1.19 ± 0.12

1.05 ± 0.13

0.94 ± 0.08

1.04 ± 0.13

0.95 ± 0.09

 Igf-1

1.01 ± 0.06

0.94 ± 0.02

1.00 ± 0.03

0.98 ± 0.06

1.03 ± 0.10

1.28 ± 0.09

1.02 ± 0.06

1.10 ± 0.05

 Tgf-β

1.01 ± 0.05

1.64 ± 0.26*

1.08 ± 0.12

1.21 ± 0.09

1.03 ± 0.09

0.96 ± 0.06

1.02 ± 0.09

0.74 ± 0.04*

 Il-4

1.05 ± 0.12

0.95 ± 0.11

1.21 ± 0.29

1.10 ± 0.25

1.03 ± 0.09

0.91 ± 0.10

Not detected

 Not detected

 Il-10

1.09 ± 0.18

1.77 ± 0.26*

0.86 ± 0.27

1.11 ± 0.19

1.04 ± 0.12

1.57 ± 0.21

1.06 ± 0.15

0.40 ± 0.07*