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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Rh-relaxin-2 attenuates degranulation of mast cells by inhibiting NF-κB through PI3K-AKT/TNFAIP3 pathway in an experimental germinal matrix hemorrhage rat model

Fig. 5

Knockdown of RXFP1 (a, c, l) by specific siRNA significantly inhibited the expression of PI3K (a, d), phosphorylated Akt (a, e), and TNFAIP3 (a, f) on the first day after intracerebroventricular injections. However, the expression of phosphorylated NF-κB (a, g) and inflammatory factors chymase (a, h), tryptase (a, i), IL-6 (a, j), and TNF-α (a, k) increased on the first day after GMH. *P < 0.05, Sham vs. RXFP1 SiRNA, #P < 0.05, GMH + vehicle vs. rh-relaxin-2, $P < 0.05, Scr SiRNA vs. RXFP1 SiRNA, one-way ANOVA, Tukey’s test, n = 6

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