Fig. 7

Caspase-1 inhibition reduced IL-1β-induced adhesion in non-toxic inflammatory conditions. VX-765 was added at concentration of 50 μM, simultaneously to treatment with IL-1β (10 ng/ml, 4 h). a VX-765 reduced the adhesion of PBMCs to BLECs monolayers. N = 10 from two independent experiments. b Medium from the treated BLECs was measured for cell death, using LDH release assay. N = 5 from a single experiment. Data presented as means normalized to control ± SEM. ***p < 0.001 vs. control and ##p < 0.01 vs. IL-1β