Fig. 3
From: Neuroprotective effect of astrocyte-derived IL-33 in neonatal hypoxic-ischemic brain injury
ST2 deficiency aggravates HI-induced brain injury in neonatal mice. a TTC staining and infarct volumes in WT and ST2−/− mice treated with or without IL-33 at 7 days post HI (n = 12 per group). b Representative images of Neun (red) and TUNEL (green) in the cerebral cortex of WT and ST2−/− mice at 7 days post HI (left). Scale bar, 25 μm. Right, quantification of Neun and TUNEL dual-labeled cells at 7 days post HI (n = 9 per group). c–e Neurobehavioral outcomes of the geotaxis reflex (left), cliff avoidance reaction (middle), and grip test (right) at 1, 3, and 7 days after HI (n = 9 per group). Data are mean ± SEM. *P < 0.05 compared to WT. n.s. not significant