Fig. 5
Post-CA immune homeostasis and bacterial load in the lung in MCC950-treated mice. Mice were subjected to sham or CA/CPR surgery. After 15 minutes reperfusion, mice received intraperitoneal injection of MCC950 (treated) or vehicle (control), followed by daily injection for 2 days. All analyses were performed on day 3 after CA/CPR. a Immune cell populations in the spleen. The following leukocyte subpopulations are shown here: T cells (CD45+CD3+), B cells (CD45+ CD19+), neutrophils (CD45+CD11b+Ly6G+), and natural killer cells (NK; CD45+CD3-NK1.1+). b Spleen weight. c Bacterial load in the lung. Representative images illustrate the colonies on blood agar plates. Data are presented as mean ± SEM (n = 5/group). *p < 0.05; **p < 0.01; ***p < 0.001