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Table 1 mRNA levels of genes encoding PRRs in brain homogenates from 18-day-old mice injected daily with 100 mg/kg body weight CBE from day 8

From: Mice defective in interferon signaling help distinguish between primary and secondary pathological pathways in a mouse model of neuronal forms of Gaucher disease

Gene Fold-change
CBE versus PBS
p value
Tlr1 7.5 ± 1.4 < 0.001
Tlr2 17.3 ± 2.8 < 0.005
Tlr3 5.0 ± 1.4 < 0.005
Tlr4 4.1 ± 0.5 < 0.001
Tlr5 1.7 ± 0.6 n.s.
Tlr6 3.7 ± 2.0 n.s.
Tlr7 6 ± 1.8 < 0.001
Tlr8 3.8 ± 2.6 n.s.
Tlr9 2.4 ± 0.9 n.s.
Tlr11 1.3 ± 1.1 n.s.
Tlr12 1.1 ± 0.4 n.s.
Tlr13 9.1 ± 1.5 < 0.001
Rig-I 6.6 ± 1.5 < 0.005
Mda5 8.4 ± 2.3 < 0.005
Nod2 2.7 ± 0.8 < 0.05
cGAS 3.1 ± 0.6 0.005
Sting 2.8 ± 0.8 < 0.05
  1. Results are expressed as fold-change of CBE-versus PBS-injected mice (n = 3) and are means ± SEM
  2. n.s. not significant