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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Astrocyte remodeling in the beneficial effects of long-term voluntary exercise in Alzheimer’s disease

Fig. 3

Effect of voluntary physical exercise on Aβ load and glial activation in hippocampi. Representative images of Aβ (a, red), GFAP-positive astrocytes (c, green), Iba1-positive microglia (e, green), and DAPI (blue) in the hippocampal area of WT-SED, WT-EXE, 5xFAD-SED, 5xFAD-EXE mice. Solid and dotted lines represent quantified hippocampi and subiculum areas, respectively. Scale bars: 200 μm. Aβ (b), Iba1 (d), and GFAP (f) levels were quantified by measuring the percentage of positive immunoreactive area in hippocampi and subiculum. All data are presented as mean (± SEM). Two-way ANOVA used to measure genotype and exercise effect between WT and 5xFAD mice followed by unpaired t test comparison in case of significant interaction between two factors (genotype*exercise). n = 8/group, «*» Genotype effect, «#» exercise effect: **p < 0.01, ***p < 0.001, #p < 0.05, ##p < 0.01

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