Skip to main content

Table 1 Parameters (means ± S.D.) of the stimulus-response curve determined from tail and plantar muscles in n (numbers in parentheses) EAE (MOG) mice, compared to control (CFA) animals, 2 and 4 weeks after immunization

From: Alterations of peripheral nerve excitability in an experimental autoimmune encephalomyelitis mouse model for multiple sclerosis

 

2 weeks

4 weeks

CFA-mice (6)

MOG-mice (6)

CFA-mice (6)

MOG-mice (5)

Tail muscle

CMAPmax (mV)

6.922 ± 0.773

3.893 ± 0.544*

5.992 ± 0.469

3.787 ± 0.511*

SI-50% (mA)

0.222 ± 0.014

0.179 ± 0.006*

0.224 ± 0.015

0.166 ± 0.013*

Slope

5.226 ± 0.451

3.258 ± 0.515*

4.977 ± 0.238

3.982 ± 0.112*

Latency (ms)

3.854 ± 0.067

3.703 ± 0.104

3.987 ± 0.130

3.818 ± 0.075

Plantar muscle

CMAPmax (mV)

6.075 ± 0.650

3.204 ± 0.513**

5.635 ± 0.588

3.011 ± 0.522*

SI-50% (mA)

0.278 ± 0.023

0.174 ± 0.010**

0.320 ± 0.014

0.231 ± 0.013**

Slope

6.261 ± 0.650

3.559 ± 0.405*

5.756 ± 0.337

4.051 ± 0.206**

Latency (ms)

3.044 ± 0.201

3.625 ± 0.223

3.286 ± 0.147

3.346 ± 0.205

  1. CMAPmax maximal CMAP amplitude, SI-50% stimulation intensity necessary to generate a CMAP with an amplitude equal to 50% of its maximum value, Slope slope of the stimulus-response curve, Latency time between the stimulus onset and the first peak amplitude of CMAP. *P ≤ 0.048 and **P ≤ 0.007
Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094