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Table 1 Parameters (means ± S.D.) of the stimulus-response curve determined from tail and plantar muscles in n (numbers in parentheses) EAE (MOG) mice, compared to control (CFA) animals, 2 and 4 weeks after immunization

From: Alterations of peripheral nerve excitability in an experimental autoimmune encephalomyelitis mouse model for multiple sclerosis

  2 weeks 4 weeks
CFA-mice (6) MOG-mice (6) CFA-mice (6) MOG-mice (5)
Tail muscle
CMAPmax (mV) 6.922 ± 0.773 3.893 ± 0.544* 5.992 ± 0.469 3.787 ± 0.511*
SI-50% (mA) 0.222 ± 0.014 0.179 ± 0.006* 0.224 ± 0.015 0.166 ± 0.013*
Slope 5.226 ± 0.451 3.258 ± 0.515* 4.977 ± 0.238 3.982 ± 0.112*
Latency (ms) 3.854 ± 0.067 3.703 ± 0.104 3.987 ± 0.130 3.818 ± 0.075
Plantar muscle
CMAPmax (mV) 6.075 ± 0.650 3.204 ± 0.513** 5.635 ± 0.588 3.011 ± 0.522*
SI-50% (mA) 0.278 ± 0.023 0.174 ± 0.010** 0.320 ± 0.014 0.231 ± 0.013**
Slope 6.261 ± 0.650 3.559 ± 0.405* 5.756 ± 0.337 4.051 ± 0.206**
Latency (ms) 3.044 ± 0.201 3.625 ± 0.223 3.286 ± 0.147 3.346 ± 0.205
  1. CMAPmax maximal CMAP amplitude, SI-50% stimulation intensity necessary to generate a CMAP with an amplitude equal to 50% of its maximum value, Slope slope of the stimulus-response curve, Latency time between the stimulus onset and the first peak amplitude of CMAP. *P ≤ 0.048 and **P ≤ 0.007