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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: CRID3, a blocker of apoptosis associated speck like protein containing a card, ameliorates murine spinal cord injury by improving local immune microenvironment

Fig. 2

Effect of CRID3 on the number and status of microglia and infiltrated macrophages in the injured spinal cord as distinguished by IHF. (a-f) Representative images of CD11b (red) and CD68 (green) (a-c) or CD45 (e-f) expression in the spinal cords in sham, SCI (vehicle), and SCI (CRID3) groups. Cells were counterstained with Hoechst 33342 (blue) to visualize nuclei. (g-k) Quantitative analysis of CD45+ (g), CD68+ (h), CD11b+ (i), CD68+CD11b+ (j), and CD45+CD11b+ (k) cells in the indicated groups. Data represent the mean ± SD (n = 6). *P < 0.05, **P < 0.01 (non-parametric Kruskal-Wallis ANOVA, followed by individual Mann-Whitney U tests)

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Journal of Neuroinflammation

ISSN: 1742-2094