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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: CRID3, a blocker of apoptosis associated speck like protein containing a card, ameliorates murine spinal cord injury by improving local immune microenvironment

Fig. 5

Effect of CRID3 on M1 and M2 cells in the injured spinal cord as distinguished by FCM. a Representative images of FCM in the spinal cords in sham, SCI (vehicle), and SCI (CRID3) groups. In the CD11b/SSC pseudocolor plots, the same size “region” of the nucleated CD11b+ cells was set for each sample, and then analyzed the proportion of each cell population in CD68/CCR7 and CD45/CD11b pseudocolor plots, respectively. In the CD45/CD11b pseudocolor plots, the “regions” of the CD11b+CD45−/low cells (R1) and CD11b+CD45high cells (R2) for each sample were further analyzed for the proportion of each cell population in CD68/CCR7. b Quantitative analysis of the indicated cells in the indicated groups. Data represent the mean ± SD (n = 6). **P < 0.01 (non-parametric Kruskal-Wallis ANOVA, followed by individual Mann-Whitney U tests)

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