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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: CRID3, a blocker of apoptosis associated speck like protein containing a card, ameliorates murine spinal cord injury by improving local immune microenvironment

Fig. 6

Effect of CRID3 on Th1, Th2, and Th17 cells in the injured spinal cord as distinguished by IHF. (a-f) Representative images of CD4 (green) and T-bet (red) (a-c) or GATA3 (red) (e-f) or (RORγ-t) (red) (i-k) expression in the spinal cords in sham, SCI (vehicle), and SCI (CRID3) groups. Cells were counterstained with Hoechst 33342 (blue) to visualize nuclei. (d, h, and l) Quantitative analysis of CD4+T-bet+ (d), CD4+GATA3+ (h), and CD4+RORγ-t+ (l) cells in the indicated groups. Data represent the mean ± SD (n = 6). *P < 0.05, **P < 0.01 (non-parametric Kruskal-Wallis ANOVA, followed by individual Mann-Whitney U tests)

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