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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Microglial-associated responses to comorbid amyloid pathology and hyperhomocysteinemia in an aged knock-in mouse model of Alzheimer’s disease

Fig. 2

Dietary-induced HHcy alters the amyloid plaque size distribution in KI mice. a Plaques within each ROI were binned into three ranges: 10–300 μm2, 301–900 μm2, and 901 μm2 or greater, and compared across dietary condition. The average number of plaques in the first two ranges was significantly increased in the cortex of KI mice on HHcy versus control diet. Two-way mixed measures ANOVA with Sidak’s post hoc testing, n = 11 control and 10 HHcy mice, *p < .05. There was also an increase in small plaques in the hippocampus but the increase did not reach significance. b Cumulative probability histograms were generated for the complete set of analyzed plaques across animals within each dietary condition, showing that in the cortex there is a slight leftward shift in the distribution, indicative of an increase in smaller-sized plaques. Kolmogorov-Smirnov test, n = 1727 control and 3399 HHcy plaques in the cortex, and n = 741 control and 1264 plaques in the hippocampus, **p < .01

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