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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Microglial-associated responses to comorbid amyloid pathology and hyperhomocysteinemia in an aged knock-in mouse model of Alzheimer’s disease

Fig. 3

Dietary-induced HHcy increases hippocampal IL-1β in KI mice. Levels of cortical (a) and hippocampal (b) IL-1β, IL-6, TNFα, CXCL1, IL-33, and CCL3 are shown in response to diet and genotype. IL-1β levels in cortex are higher in KI mice compared to WT mice, but there is no additional effect of HHcy diet in this region. In contrast, IL-1β levels are significantly increased by HHcy diet in the hippocampus of KI mice but not WT mice. CCL3 was elevated in both cortex and hippocampus of KI versus WT mice, but diet did not alter the effect of genotype on this chemokine. *p < .05, ***p < .005, ****p < .001 versus corresponding WT dietary group, p < .05 versus KI control, two-way ANOVA with Sidak’s post hoc tests, n = 8–11 per group

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