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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Microglial-associated responses to comorbid amyloid pathology and hyperhomocysteinemia in an aged knock-in mouse model of Alzheimer’s disease

Fig. 4

Dietary-induced HHcy is associated with a moderate decrease in cortical P2ry12 staining in KI mice. Representative images of cortex from a WT mouse on control diet (WT control) and KI mouse on control diet (KI control) are shown in a, with P2ry12 in green and DAPI in blue. A measurement mask is shown with output of the analysis algorithm shown in yellow. Total % positive area is quantified for the cortex and hippocampus in b. *p < .05 versus WT control mice, two-way ANOVA with Sidak’s post hoc tests, n = 7–10 per group due to exclusion of slides with out-of-focus areas within the ROIs

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