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Fig. 12 | Journal of Neuroinflammation

Fig. 12

From: Blocking glycine receptors reduces neuroinflammation and restores neurotransmission in cerebellum through ADAM17-TNFR1-NF-κβ pathway

Fig. 12

Proposed pathway by which extracellular cGMP through the inhibition of glycine receptors reduces neuroinflammation and restores neurotransmission in the cerebellum of hyperammonemic rats through an ADAM17-TNFR1-NF-kB pathway in Purkinje neurons. The effects of cGMP are the same induced by strychnine, indicating that enhanced glycinergic neurotransmission in hyperammonemia would be due to reduced extracellular cGMP. The effects of hyperammonemia are indicated by red arrows (↑). The effects of cGMP by the yellow symbol

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Journal of Neuroinflammation

ISSN: 1742-2094