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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Blocking glycine receptors reduces neuroinflammation and restores neurotransmission in cerebellum through ADAM17-TNFR1-NF-κβ pathway

Fig. 8

Extracellular cGMP normalizes membrane expression of ADAM17 and TNFR1 in cerebellar slices of hyperammonemic rats. Membrane expression of ADAM17 (a) and TNFR1 (b) were analyzed using BS3 cross-linker procedure in slices from control and hyperammonemic (HA) rats treated or not with extracellular cGMP as described in the “Methods” section. Values are the mean ± SEM of 20–39 rats per group. Values significantly different from control rats are indicated by asterisk and from hyperammonemic rats are indicated by “a”. *p < 0.05, **p < 0.01; aa p < 0.01, aaaa p < 0.0001. Data were analyzed using a one-way analysis of variance (ANOVA) followed by Turkey post hoc

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Journal of Neuroinflammation

ISSN: 1742-2094