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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Deficiency of the microglial Hv1 proton channel attenuates neuronal pyroptosis and inhibits inflammatory reaction after spinal cord injury

Fig. 7

A ROS scavenger rescues ROS-mediated NLRP3 inflammasome activation. a Western blotting showing NLRP3, ASC, caspase-1 p20, and IL-18 levels. b–d Quantification of Western-blot analysis for NLRP3 (b), ASC (c), and caspase-1 p20 (d) normalized to GAPDH. e Relative caspase-1 activity after different treatments. f Quantification of Western-blot analysis for IL-18 normalized to GAPDH. Data are represented as the mean ± SEM (n = 5 for each treatment; #p < 0.05 ##p < 0.01, OGD/R vs. control; *p < 0.05 **p < 0.01, OGD/R + NAC vs. OGD/R)

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Journal of Neuroinflammation

ISSN: 1742-2094