The envelope protein of tick-borne encephalitis virus influences neuron entry, pathogenicity, and vaccine protection

Table 1 Description of the different TBEV strains used in the study

Virus strain	TBEV subtype	Source of isolation	Year of isolation	Country of isolation	Passage history	Reference
Torö-2003 (from now on denoted Torö)	European	I. ricinus	2003	Sweden	Infectious clone [29], 2 passages in VeroB4 cells	[27, 29] GenBank Accession no. DQ401140.3
HM467/09	European	I. ricinus	2009	Germany	3 passages in VeroB4 cells	JF501446.1 [34]
Neudörfl	European	I. ricinus	1970	Austria	Multiple lab passages in mouse brain and call culture	[35]
Hypr71 (from now on denoted Hypr)	European	Human blood	1953	Czechoslovakia	Multiple lab passages in mouse brain and cell culture	[36]
AS33	European	I. ricinus	2005	Germany	7 passages in VeroB4 cells	[37] GenBank Accession no GQ266392.1
93/783	European	Serum of a 56-year-old male	1993	Sweden	Isolation in suckling mouse brain, 4 passages in VeroB4 cells	[26] GenBank Accession no MT581212.1
M14/10	Siberian	I. persulcatus	2010	Mongolia	7 passages in VeroB4 cells	[38]
Aina	Siberian	Human blood	1963	Russia	Multiple lab passages in mouse brain and cell culture	[39]
Sofjin	Far Eastern	Human brain		Russia	Multiple lab passages in mouse brain and cell culture	[40]

ISSN: 1742-2094