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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Cottonseed oil alleviates ischemic stroke injury by inhibiting the inflammatory activation of microglia and astrocyte

Fig. 4

CSO treatment relieved the physiological conditions of BBB in the ischemic penumbra. A CSO pretreatment increases VE-cadherin protein and reduces AQP4 and Claudin-1 protein expression in the ischemic penumbra 24 h after reperfusion. A (a) Cropped gels and blots showing the protein expression of the VE-cadherin, AQP4, and Claudin-1. A(b) Graph of the protein expression of the VE-cadherin, AQP4, and Claudin-1. ###p < 0.001, ##p < 0.01, #p < 0.05 vs. Sham-Con group, **p < 0.01, *p < 0.05 vs. MCAO-Con group. n = 6 per group. B Representative transmission electron micrographs showing the high-magnification images of ultrastructural changes in different groups of rats. Red arrowheads indicate disruption of the plasma membrane, basal membrane, gap junctions, organelles, accumulation of glycogen, and swollen endothelial cytoplasm. Black arrowheads indicate intact vascular ultrastructure. A: astrocyte end-feet; B: basal lamina; E: endothelial cell; L: lumen. Scale bar = 2 μm. n = 3 per group

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