Fig. 7From: GM2 ganglioside accumulation causes neuroinflammation and behavioral alterations in a mouse model of early onset Tay-Sachs diseaseMorris water maze test. Latency to target for the visible platform (a and c) and hidden platform (b and d), swim speed (e and f), and distance to the target (g and h) were analyzed. Typical swim patterns of 2.5- and 4.5-month-old mice on day 8 were shown (i and j, respectively). The data are presented as means + SEM. A 2.5-month-old WT (n = 4), Hexa−/− (n = 8), Neu3−/− (n = 3), and Hexa−/−Neu3−/− (n = 3) mice; 4.5-month-old WT (n = 6), Hexa−/− (n = 3), Neu3−/− (n = 3), and Hexa−/−Neu3−/− (n = 3)Back to article page