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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: β-Hydroxybutyrate inhibits inflammasome activation to attenuate Alzheimer’s disease pathology

Fig. 1

AD patients have less BHB in their blood and brain parenchyma. Volcano plots showing the relative concentration of various metabolites detected in the red blood cells (a) and brain parenchyma (b) of AD patients compared with non-AD controls (CTRL). Relative expression is on the x-axis with significance on the y-axis. Graphs showing relative concentration of BHB in blood (c) and brain parenchyma (d) of AD patients compared with non-AD CTRL. Data are shown as mean ± SEM with ***P ≤ 0.001 and **P ≤ 0.01. (e) Correlation of BHB concentration in the brain of AD and non-AD CTRL with blood of AD and non-AD CTRL showing a strong, positive correlation of BHB in the brain and blood, with an R2 value of 0.9353. All data represent results taken from AD patients (n = 10) and non-AD CTRL (n = 10)

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