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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Site-specific opening of the blood-brain barrier by extracellular histones

Fig. 7

Membrane surface charge affects histone-induce changes in endothelial permeability. TEER measurements across confluent monolayers of brain endothelial cells treated with vehicle (saline) or histones (100 μg/mL) in the presence of a cholesterol sulfate (200 μM) and b oleylamine (200 μM). Mean ± S.E.M. c Confocal microscopy images of brain endothelial cells showing claudin-5 immunostaining after vehicle or fluorescently labeled histone exposure in the presence of cholesterol sulfate and oleylamine (200 μM). Scale bar = 20 μm. d Cartoon summarizing how changes in membrane cationicity affect histone-induced barrier disruption in brain endothelial cells

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