Skip to main content
Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: TDP-43 mediated blood-brain barrier permeability and leukocyte infiltration promote neurodegeneration in a low-grade systemic inflammation mouse model

Fig. 4

Chronic low-grade systemic inflammation promotes neuronal loss and synaptic dysfunction in TDP-43 AAV9 mice. a Brain weights of mice during the sacrifice. b Representative images depicting the number of NeuN-positive neurons. Scale bar = 20 μm. c Quantification of neurons per field is analyzed in the frontal cortex of the mouse brain. Statistical analysis was carried out by one-way ANOVA with Bonferroni post hoc test (n = 4 mice/group; *p < 0.05). d Western blot analysis of synaptic markers in the frontal cortex of the mouse brain. e Quantification of synaptic markers. Statistical analysis was carried out by one-way ANOVA with Bonferroni post hoc test (n = 4 mice/group; *p < 0.05)

Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094