Fig. 7

LPS-induced altered cytokine signaling during TDP-43 overexpression leads to neutrophil infiltration in the brain. a The concentration of eotaxin, IL-1α, IL-1β, IL-10, VEGF, RANTES, KC-GRO, and MIP-1α in frontal cortex tissue lysates. Statistical analysis was carried out using a one-way ANOVA with Bonferroni post hoc test or two-tailed t-tests for RANTES (n = 6 mice/group; *p < 0.05, ***p < 0.001). b Representative images of Ly6B.2+ neutrophil labeling in the frontal cortex of mice. Scale bar = 10 μm. c Manual count of Ly6B.2+ neutrophils. Statistical analysis was carried out using a one-way ANOVA with Bonferroni post hoc test (n = 4 mice/group, ***p < 0.001)