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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Coding transcriptome analyses reveal altered functions underlying immunotolerance of PEG-fused rat sciatic nerve allografts

Fig. 1

Cell-type associated transcripts and differentially expressed genes (DEGs) among PEG-fused allografts, NC allografts, and unoperated control nerves. a Heatmap showing relative expression of T cell-associated transcripts and macrophage-associated transcripts among all samples using normalized read counts. Each column is a sample, and each row is a gene. Transcripts are hierarchically clustered based on expression patterns across rows. Red = high expression; blue = low expression. Transcripts with statistically significant differences in expression (padj < 0.05) when compared between PEG and NC groups are marked with an asterisk. b Heatmap showing relative expression of Schwann cell-associated transcripts. ch Normalized read counts of Schwann cell-associated transcripts that are significantly upregulated (PEG vs. NC, padj < 0.05). Horizontal bars indicate the mean. ik Volcano plots showing all DEGs between i PEG vs. NC, j PEG vs. Unop, and k NC vs. Unop. Thresholds for log2 fold changes > 1 or < − 1 and padj < 0.05 were used to identify greatly upregulated (red) or downregulated (blue) DEGs for subsequent analyses. The number of up- or downregulated DEGs in each comparison is shown above each plot. Each point represents a single gene transcript. Triangles indicate notable DEGs that have very low adjusted p values (padj)

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